Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia

Ahmed Abdel Fattah Elshoura; Hala Desouky Ibrahim; Sahar Mohey Hazzaa; Ola Abdel Fattah Elshora; Gamal Ibrahim Moussa

doi:doi:10.11648/j.js.20180604.16

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Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia

Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa

Published in Journal of Surgery (Volume 6, Issue 4)

Received: 10 July 2018 Accepted: 20 July 2018 Published: 14 August 2018

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Abstract

Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.

Published in	Journal of Surgery (Volume 6, Issue 4)
DOI	10.11648/j.js.20180604.16
Page(s)	107-111
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Acute Abdomen, Mesenteric Ischemia, α -glutathione S-transferase

References

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APA Style

Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. (2018). Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. Journal of Surgery, 6(4), 107-111. https://doi.org/10.11648/j.js.20180604.16

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ACS Style

Ahmed Abdel Fattah Elshoura; Hala Desouky Ibrahim; Sahar Mohey Hazzaa; Ola Abdel Fattah Elshora; Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J. Surg. 2018, 6(4), 107-111. doi: 10.11648/j.js.20180604.16

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AMA Style

Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J Surg. 2018;6(4):107-111. doi: 10.11648/j.js.20180604.16

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@article{10.11648/j.js.20180604.16,
  author = {Ahmed Abdel Fattah Elshoura and Hala Desouky Ibrahim and Sahar Mohey Hazzaa and Ola Abdel Fattah Elshora and Gamal Ibrahim Moussa},
  title = {Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia},
  journal = {Journal of Surgery},
  volume = {6},
  number = {4},
  pages = {107-111},
  doi = {10.11648/j.js.20180604.16},
  url = {https://doi.org/10.11648/j.js.20180604.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180604.16},
  abstract = {Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.},
 year = {2018}
}

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TY - JOUR
T1 - Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia
AU - Ahmed Abdel Fattah Elshoura
AU - Hala Desouky Ibrahim
AU - Sahar Mohey Hazzaa
AU - Ola Abdel Fattah Elshora
AU - Gamal Ibrahim Moussa
Y1 - 2018/08/14
PY - 2018
N1 - https://doi.org/10.11648/j.js.20180604.16
DO - 10.11648/j.js.20180604.16
T2 - Journal of Surgery
JF - Journal of Surgery
JO - Journal of Surgery
SP - 107
EP - 111
PB - Science Publishing Group
SN - 2330-0930
UR - https://doi.org/10.11648/j.js.20180604.16
AB - Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.
VL - 6
IS - 4
ER -

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Author Information

Ahmed Abdel Fattah Elshoura

General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Hala Desouky Ibrahim

Emergency & Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Sahar Mohey Hazzaa

Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Ola Abdel Fattah Elshora

Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Gamal Ibrahim Moussa

General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

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APA Style

Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. (2018). Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. Journal of Surgery, 6(4), 107-111. https://doi.org/10.11648/j.js.20180604.16

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ACS Style

Ahmed Abdel Fattah Elshoura; Hala Desouky Ibrahim; Sahar Mohey Hazzaa; Ola Abdel Fattah Elshora; Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J. Surg. 2018, 6(4), 107-111. doi: 10.11648/j.js.20180604.16

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AMA Style

Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J Surg. 2018;6(4):107-111. doi: 10.11648/j.js.20180604.16

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@article{10.11648/j.js.20180604.16,
  author = {Ahmed Abdel Fattah Elshoura and Hala Desouky Ibrahim and Sahar Mohey Hazzaa and Ola Abdel Fattah Elshora and Gamal Ibrahim Moussa},
  title = {Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia},
  journal = {Journal of Surgery},
  volume = {6},
  number = {4},
  pages = {107-111},
  doi = {10.11648/j.js.20180604.16},
  url = {https://doi.org/10.11648/j.js.20180604.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180604.16},
  abstract = {Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.},
 year = {2018}
}

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