Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein.
| Published in | Journal of Food and Nutrition Sciences (Volume 9, Issue 6) |
| DOI | 10.11648/j.jfns.20210906.13 |
| Page(s) | 153-162 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Remnant Lipoprotein-Cholesterol, Apolipoprotein B48, Apolipoprotein C-III, Insulin Sensitivity, Insulin Resistance
| [1] | Saito H, Kagaya M, Suzuki M, Yoshida A, Naito M: Simultaneous ingestion of fructose and fat exacerbates postprandial exogenous lipidemia in young healthy Japanese women. J Atheroscler Thromb, 2013; 20: 591-600. |
| [2] | Kuzawa K, Sui L, Hossain A, Kamitori K, Tsukamoto I, Yoshida A, Tokuda M, Naito M: Effects of a rare sugar, D-allulose, coingested with fat on postprandial glycemia and lipidemia in young women. J Nutr Hum Health, 2019; 3: 1-6. |
| [3] | O'Keefe JH, Bell DS: Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol, 2007; 100: 899-904. |
| [4] | American Diabetes Association: Standards of medical care in diabetes–2016 abridged for primary care providers. Clin Diabetes, 2016; 34: 3-21. |
| [5] | Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y: Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama study. Stroke, 2010; 41: 203-209. |
| [6] | Cavalot F, Petrelli A, Traversa M, Bonomo K, Fiora E, Conti M, Anfossi G, Costa G, Trovati M: Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study. J Clin Endocrinol Metab, 2006; 91: 813-819. |
| [7] | Genest JJ, McNamara JR, Salem DN, Schaefer EJ: Prevalence of risk factors in men with premature coronary artery disease. Am J Cardiol, 1991; 67: 1185-1189. |
| [8] | Miller M, Seidler A, Moalemi A, Pearson TA: Normal triglyceride levels and coronary artery disease events: the Baltimore Coronary Observational Long-Term Study. J Am Coll Cardiol, 1998; 31: 1252-1257. |
| [9] | Schaefer EJ, Lamon-Fava S, Cohn SD, Schaefer MM, Ordovas JM, Castelli WP, Wilson PW: Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study. J Lipid Res, 1994; 35: 779-792. |
| [10] | Mora S, Rifai N, Buring JE, Ridker PM: Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events. Circulation, 2008; 118: 993-1001. |
| [11] | Brunzell JD, Hazzard WR, Porte D Jr, Bierman EL: Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J Clin Invest, 1973; 52: 1578-1585. |
| [12] | Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A: Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA, 2007; 298: 299-308. |
| [13] | Freiberg JJ, Tybjaerg-Hansen A, Jensen JS, Nordestgaard BG: Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA, 2008; 300: 2142-2152. |
| [14] | Langsted A, Freiberg JJ, Tybjaerg-Hansen A, Schnohr P, Jensen GB, Nordestgaard BG: Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up. J Intern Med, 2011; 270: 65-75. |
| [15] | McNamara JR, Shah PK, Nakajima K, Cupples LA, Wilson PW, Ordovas JM, Schaefer EJ: Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study. Atherosclerosis, 2001; 154: 229-236. |
| [16] | LaRosa JC: Triglycerides and coronary risk in women and the elderly. Arch Intern Med, 1997; 157: 961-968. |
| [17] | Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy M-A, Simonson DC, Creager MA: Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation, 1998; 97: 1695-1701. |
| [18] | Bae JH, Bassenge E, Kim KB, Kim YN, Kim KS, Lee HJ, Moon KC, Lee MS, Park KY, Schwemmer M: Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis, 2001; 155: 517-523. |
| [19] | Ceriello A, Genovese S: Atherogenicity of postprandial hyperglycemia and lipotoxicity. Rev Endocr Metab Disord, 2016; 17: 111-116. |
| [20] | Asano M, Fukakura N, Odachi J, Kawaraya C, Nanba A, Yasuda N, Yamamoto E: Use of fast foods among young people. Jpn J Nutr Diet, 2003; 61: 47-54 (In Japanese, Abstract in English). |
| [21] | Nabeno-Kaeriyama Y, Fukuchi Y, Hayashi S, Kimura T, Tanaka A, Naito M: Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men. Clin Chim Acta, 2010; 411: 1694-1699. |
| [22] | Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985; 28: 412-419. |
| [23] | Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab, 2000; 85: 2402-2410. |
| [24] | Nakatani K, Sugimoto T, Masuda D, Okano R, Oya T, Monden Y, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Yuasa-Kawase M, Tsubakio-Yamamoto K, Ohama T, Nishida M, Ishigami M, Komuro I, Yamashita S: Serum apolipoprotein B-48 levels are correlated with carotid intima-media thickness in subjects with normal serum triglyceride levels. Atherosclerosis, 2011; 218: 226-232. |
| [25] | Batal R, Tremblay M, Barrett PHR, Jacques H, Fredenrich A, Mamer O, Davignon J, Cohn JS: Plasma kinetics of ApoC-III and ApoE in normolipidemic and hypertriglyceridemic subjects. J Lipid Res, 2000; 41: 706-718. |
| [26] | Chan DC, Watts GF, Barrett PH, Mamo JCL, Redgrave TG: Markers of triglyceride-rich lipoprotein remnant metabolism in visceral obesity. Clin Chem, 2002; 48: 278-283. |
| [27] | Chivot L, Mainard F, Bigot E, Bard JM, Auget JL, Madec Y, Fruchart JC: Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E. Atherosclerosis, 1990; 82: 205-211. |
| [28] | Hodis HN, Mack WJ, Azen SP, Alaupovic P, Pogoda JM, LaBree L, Hemphill LC, Kramsch DM, Blankenhorn DH: Triglyceride- and cholesterol-rich lipoproteins have a differential effect on mild/moderate and severe lesion progression as assessed by quantitative coronary angiography in a controlled trial of lovastatin. Circulation, 1994; 90: 42-49. |
| [29] | Luc G, Fievet C, Arveiler D, Evans AE, Bard JM, Cambien F, Fruchart JC, Ducimetiere P: Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study. Etude Cas Témoins sur 'Infarctus du Myocarde. J Lipid Res, 1996; 37: 508-517. |
| [30] | Korena E, Corder C, Mueller G, Centurion H, Hallum G, Fesmire J, McConathy WD, Alaupovic P: Triglyceride enriched lipoprotein particles correlate with the severity of coronary artery disease. Atherosclerosis, 1996; 122: 105-115. |
| [31] | Sacks FM, Alaupovic P, Moye LA, Cole TG, Sussex B, Stampfer MJ, Pfeffer MA, Braunwald E: VLDL, Apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) Trial. Circulation, 2000; 102: 1886-1892. |
| [32] | Onat A, Hergenç G, Sansoy V, Fobker M, Ceyhan K, Toprak S, Assmann G: Apolipoprotein C-III, a strong discriminant of coronary risk in men and a determinant of the metabolic syndrome in both genders. Atherosclerosis, 2003; 168: 81-89. |
| [33] | Cohn JS, Johnson EJ, Millar JS, Cohn SD, Milne RW, Marcel YL, Russell RM, Schaefer EJ: Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J Lipid Res, 1993; 34: 2033-2040. |
| [34] | Cohn JS, McNamara JR, Cohn SD, Ordovas JM, E J Schaefer EJ: Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fat-rich meal. J Lipid Res, 1988; 29: 925-936. |
| [35] | Karpe F, Bell M, Björkegren J, Hamsten A: Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arterioscler Thromb Vas Biol, 1995; 15: 199–207. |
| [36] | Schneeman BO, Kotite L, Todd KM, Havel RJ: Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proc Natl Acad Sci USA, 1993; 90: 2069-2073. |
| [37] | Evans K, Kuusela PJ, Cruz ML, Wilhelmova I, Fielding BA, Frayn KN: Rapid chylomicron appearance following sequential meals: effects of second meal composition. Br J Nutr, 2007; 79: 425-429. |
| [38] | Heath RB, Karpe F, Milne RW, Burdge GC, Wootton SA, Frayn KN: Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state. Am J Physiol Endocrinol Metab, 2007; 292: E732-739. |
| [39] | Martins IJ, Sainsbury AJ, Mamo JCL, Redgrave TG: Lipid and apolipoprotein B48 transport in mesenteric lymph and the effect of hyperphagia on the clearance of chylomicron-like emulsions in insulin-deficient rats. Diabetologia, 1994; 37: 238-246. |
| [40] | Guo Q, Avramoglu RK, Adeli K: Intestinal assembly and secretion of highly dense/lipid-poor apolipoprotein B48-containing lipoprotein particles in the fasting state: Evidence for induction by insulin resistance and exogenous fatty acids. Metabolism, 2005; 54: 689-697. |
| [41] | Hashimoto S, Hayashi S, Yoshida A, Naito M: Acute effects of postprandial aerobic exercise on glucose and lipoprotein metabolism in healthy young women. J Atheroscler Thromb, 2013; 20: 204-213. |
| [42] | Nestel PJ: Relationship between plasma triglycerides and removal of chylomicrons. J Clin Invest, 1964; 43: 943-949. |
| [43] | Grundy SM, Mok HYI: Chylomicron clearance in normal and hyperlipidemic man. Metabolism, 1976; 1225-1239. |
| [44] | Hultin M, Savonen R, Olivecrona T: Chylomicron metabolism in rats: lipolysis, recirculation of triglyceride-derived fatty acids in plasma FFA, and fate of core lipids as analyzed by compartmental modelling. J Lipid Res, 1996; 37: 1022-1036. |
| [45] | Welty FK, Lichtenstein AH, Barrett PHR, Dolnikowski GG, Schaefer EJ: Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes. Arterioscler Thromb Vasc Biol, 1999; 19: 2966-2974. |
| [46] | Musunuru K, Kathiresan S: Surprises from genetic analyses of lipid risk factors for atherosclerosis. Circ Res, 2016; 118: 579-585. |
| [47] | Griffin BA: Lipoprotein atherogenicity: an overview of current mechanisms. Proc Nutr Soc, 1999; 58: 163-169. |
| [48] | Sattar N, Greer IA, Louden J, Lindsay G, McConnell M, Shepherd J, Packard CJ: Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small, dense low density lipoprotein. J Clin Endocrinol Metab, 1997; 82: 2483-2491. |
| [49] | Millar JS, Packard CJ: Heterogeneity of apolipoprotein B-100-containing lipoproteins: what we have learnt from kinetic studies. Curr Opin Lipidol, 1998; 9: 197-202. |
| [50] | Vaarhorst AM, Beekman M, Suchiman EHD, van Heemst D, Houwing-Duistermaat JJ, Westendorp RGJ, Slagboom PE, Heijmans BT, On behalf of the project group and the Leiden Longevity Study (LLS) Group: Lipid metabolism in long-lived families: the Leiden Longevity Study. Age, 2011; 33: 219-227. |
| [51] | Patsch JR, Karlin JB, Scott LW, Smith LC, Gotto Jr AM: Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. Proc Natl Acad Sci USA, 1983; 80: 1449-1453. |
| [52] | Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C: Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis, 1990; 10: 497-511. |
| [53] | Ryu JE, Craven TE, MacArthur RD, Hinson WH, Bond MG, Hagaman AP, Crouse JR III: Relationship of intraabdominal fat as measured by magnetic resonance imaging to postprandial lipemia in middle-aged subjects. Am J Clin Nutr, 1994; 60: 586-591. |
| [54] | Couillard C, Bergeron N, Prud'homme D, Bergeron J, Tremblay A, Bouchard C, Mauriège, Després JP: Postprandial triglyceride response in visceral obesity in men. Diabetes, 1998; 47: 953-960. |
| [55] | Ginsberg HN, Fishe EA: The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism. J Lipid Res, 2009; 50: S162-S166. |
| [56] | Xiao C, Dash S, Morgantini C, Lewis GF: Novel role of enteral monosaccharides in intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol, 2013; 33: 1056-1062. |
APA Style
Kaori Kuzawa, Yukino Morita, Natsuko Ichikawa, Michitaka Naito. (2021). Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. Journal of Food and Nutrition Sciences, 9(6), 153-162. https://doi.org/10.11648/j.jfns.20210906.13
ACS Style
Kaori Kuzawa; Yukino Morita; Natsuko Ichikawa; Michitaka Naito. Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. J. Food Nutr. Sci. 2021, 9(6), 153-162. doi: 10.11648/j.jfns.20210906.13
AMA Style
Kaori Kuzawa, Yukino Morita, Natsuko Ichikawa, Michitaka Naito. Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women. J Food Nutr Sci. 2021;9(6):153-162. doi: 10.11648/j.jfns.20210906.13
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Download@article{10.11648/j.jfns.20210906.13,
author = {Kaori Kuzawa and Yukino Morita and Natsuko Ichikawa and Michitaka Naito},
title = {Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women},
journal = {Journal of Food and Nutrition Sciences},
volume = {9},
number = {6},
pages = {153-162},
doi = {10.11648/j.jfns.20210906.13},
url = {https://doi.org/10.11648/j.jfns.20210906.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20210906.13},
abstract = {Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein.},
year = {2021}
}
TY - JOUR T1 - Simultaneous Evaluation of Postchallenge Glycemia and Lipidemia in Young Women AU - Kaori Kuzawa AU - Yukino Morita AU - Natsuko Ichikawa AU - Michitaka Naito Y1 - 2021/12/10 PY - 2021 N1 - https://doi.org/10.11648/j.jfns.20210906.13 DO - 10.11648/j.jfns.20210906.13 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 153 EP - 162 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20210906.13 AB - Aim: To determine the effects of simultaneously ingesting glucose and fat on postchallenge glycemia and lipidemia in 12 healthy young Japanese women. Methods: Three test trials were administered in a randomized crossover design: glucose (1 g/kg, G trial); fat cream (0.35 g/kg as fat; F trial); glucose + fat cream (GF trial). Blood samples were taken before and at 0.5, 1, 2, 4, and 6 h post-ingestion. Results: The GF trial's serum glucose peak value was lower than the G trial's, and its remnant lipoprotein-cholesterol (RLP-C) increase was less than the F trial's. The GF trial's apolipoprotein (Apo) B48 increase happened faster than the F trial's. The G and GF trials' insulinogenic index (I/G30) values were negatively correlated with the area under the curve (AUC) of glucose for 2 h. Fasting insulin level and HOMA-IR were positively (and QUICKI and I/G30 were negatively) correlated with the AUC of insulin for 2 h. The F and GF trials' fasting TG, RLP-C, ApoB48, and ApoC-III levels were positively correlated with the AUC of TG and RLP-C for 6 h. The fasting ApoB48 level predicted the AUC of ApoB48 for 6 h. Conclusion: The glucose peak was ameliorated by co-ingesting fat. I/G30 predicted an early postchallenge (0–2 h) glucose rise. The fasting insulin level, HOMA-IR, QUICKI, and I/G30 predicted an insulin rise. The RLP-C rise by fat ingestion was ameliorated by co-ingesting glucose. Fasting TG, RLP-C, ApoB48, and ApoC-III levels predicted postchallenge TG and RLP-C rises. The fasting ApoB48 level predicted postchallenge apoB48, i.e., a rise in intestinal lipoprotein. VL - 9 IS - 6 ER -
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