Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules

Naglaa Samy Fahmy; Mohamed Ahmed Yousef; Mohamed Abd El-Hamid Alm El-Din; Abd El Monem Nooman Darweesh

doi:doi:10.11648/j.ijmi.20190701.11

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Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules

Naglaa Samy Fahmy, Mohamed Ahmed Yousef, Mohamed Abd El-Hamid Alm El-Din, Abd El Monem Nooman Darweesh

Published in International Journal of Medical Imaging (Volume 7, Issue 1)

Received: 15 December 2018 Accepted: 9 January 2019 Published: 13 February 2019

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Abstract

The current study aim is the role of multi-slice CT perfusion in assessment of pulmonary nodules. Eighty patients with pulmonary nodules underwent non contrast CT scan of the chest and dynamic CT perfusion of the chest. Dynamic CT chest perfusion of 80 patients with pulmonary nodules revealed 24 patients had benign nodules of low biological activity, 16 patients had benign nodules of high biological activity and 40 patients had malignant nodules (16 of them had multiple nodules in both lung fields and clinical history of primary extra pulmonary malignancy, so diagnosed as metastatic nodules). Perfusion flow, extraction fraction and blood volume; these indexes showed significant differences between malignant nodules and benign nodules with low biologic activity (P>0.0001) In addition, these indexes showed a significant difference between benign nodules with high biologic activity and those with low biologic activity (P>0.0001) and the perfusion flow was of high benefit for nodules characterization than ejection fraction and blood volume by the higher significant values. CT perfusion compared the effect of therapy (chemotherapy and or radiotherapy) on metastatic pulmonary nodules before and after start of treatment by perfusion parameters (perfusion flow, extraction fraction and blood volume) & colour maps with the clinical data and follow up revealed that both results closely near and raise the efficacy of CT perfusion study in follow up and assessment of treatment response in metastatic pulmonary nodules. It can be concluded that CT perfusion is a feasible non-invasive diagnostic technique able to evaluate the nature of pulmonary nodules and treatment response in patients with metastatic pulmonary nodules.

Published in	International Journal of Medical Imaging (Volume 7, Issue 1)
DOI	10.11648/j.ijmi.20190701.11
Page(s)	1-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

CT Perfusion, Perfusion Flow, Extraction Fraction

References

[1]	Wang G, Zhou X, Zhao R. Multi-slice spiral computed tomography perfusion imaging technology differentiates benign and malignant solitary pulmonary nodules. Biomedical Research. 2017; 28 (10): 4605-4609.
[2]	Ohno Y, Koyama H, Matsumoto K, et al: Differentiation of Malignant and Benign Pulmonary Nodules with Quantitative First-Pass 320-Detector Row Perfusion CT versus FDG PET/CT. Radiology. 2011; 258:599-609.
[3]	Kim SH. and Kamaya A. CT Perfusion: principles and applications in oncology. Radiology. 2014; 272(2):322–344.
[4]	Yuan X, Zhang J, Quan C, et al. Differentiation of malignant andbenign pulmonary nodules with first-passdual-input perfusion CT. Eur Radiol 2013;23(9):2469–2474.
[5]	Ohno Y, Koyama H, Fujisawa Y, et al. Dynamic contrast enhanced perfusion area detector CT for non-small cell lung cancer patients: influence of mathematical models on early prediction capabilities for treatment response and recurrence after chemoradiotherapy, Eur. J. Radiol. 2016; 85(1):176–186.
[6]	Gould MK, Donington J, Lynch WR, et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest physicians evidence based clinical practice guidelines. Chest. 2013; 143(5Suppl):e93S-e120S.
[7]	Ebenhan T, Schoeman I, Rossouw DD, et al. Evaluation of a Flexible NOTA-RGD Kit Solution Using Gallium-68 from Different 68Ge/68Ga-Generators: Pharmacokinetics and Biodistribution in Nonhuman Primatesand Demonstration of Solitary Pulmonary Nodule Imaging in Humans. Mol Imaging Biol. 2017; 19 (3): 469-482.
[8]	Li Y, Yang ZG, Chen TW, et al: Whole tumour pertusion of peripheral lung carcinoma: evaluation with first-pass CT perfusion imaging at 64-detector row CT". Clin Radiol. 2008; 63: 629-35.
[9]	Yi CA, Lee KS, Kim EA, et al: Solitary pulmonary nodules: dynamic enhanced multidetector row CT study and comparison with vascular endothelial growth factor and microvessel density. Radiology 2004; 233: 191–9.
[10]	Ng QS, Goh V, Klotz E, et al: Quantitative assessment of lung cancer perfusion using MDCT: does measurement reproducibility improve with greater tumour volume coverage? AJR Am J Roentgenol 2006; 187: 1079–84.
[11]	Callister ME, Baldwin DR, Akram AR, et al: British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015; 70 Suppl 2:ii1-ii54.
[12]	Swensen SJ, Viggiano RW, Midthun DE, et al. Lung nodule enhancement at CT: multicenter study. Radiology 2000; 214: 73-80.
[13]	Erasmus JJ, Connolly JE, McAdams HP, et al: Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions. Radiographics. 2000; 20(1):43-58.
[14]	Callister ME, Baldwin DR, Akram AR, et al: British Thoracic Society guidelines for the investigation and management of pulmonary nodules. Thorax. 2015; 70 Suppl 2:ii1-ii54.
[15]	SitartchoukI, Roberts HC, Pereira AM, et al. Computed tomography perfusion using first pass methods for lung nodule characterization: limits and implications in radiologic practice. Invest Radiol. 2009; 44(2):124.
[16]	Garcia-Barros M, Paris F, Cordon-Cardo C, et al: Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003; 300(5622):1155-9.

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APA Style

Naglaa Samy Fahmy, Mohamed Ahmed Yousef, Mohamed Abd El-Hamid Alm El-Din, Abd El Monem Nooman Darweesh. (2019). Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. International Journal of Medical Imaging, 7(1), 1-10. https://doi.org/10.11648/j.ijmi.20190701.11

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ACS Style

Naglaa Samy Fahmy; Mohamed Ahmed Yousef; Mohamed Abd El-Hamid Alm El-Din; Abd El Monem Nooman Darweesh. Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. Int. J. Med. Imaging 2019, 7(1), 1-10. doi: 10.11648/j.ijmi.20190701.11

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AMA Style

Naglaa Samy Fahmy, Mohamed Ahmed Yousef, Mohamed Abd El-Hamid Alm El-Din, Abd El Monem Nooman Darweesh. Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. Int J Med Imaging. 2019;7(1):1-10. doi: 10.11648/j.ijmi.20190701.11

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@article{10.11648/j.ijmi.20190701.11,
  author = {Naglaa Samy Fahmy and Mohamed Ahmed Yousef and Mohamed Abd El-Hamid Alm El-Din and Abd El Monem Nooman Darweesh},
  title = {Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules},
  journal = {International Journal of Medical Imaging},
  volume = {7},
  number = {1},
  pages = {1-10},
  doi = {10.11648/j.ijmi.20190701.11},
  url = {https://doi.org/10.11648/j.ijmi.20190701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20190701.11},
  abstract = {The current study aim is the role of multi-slice CT perfusion in assessment of pulmonary nodules. Eighty patients with pulmonary nodules underwent non contrast CT scan of the chest and dynamic CT perfusion of the chest. Dynamic CT chest perfusion of 80 patients with pulmonary nodules revealed 24 patients had benign nodules of low biological activity, 16 patients had benign nodules of high biological activity and 40 patients had malignant nodules (16 of them had multiple nodules in both lung fields and clinical history of primary extra pulmonary malignancy, so diagnosed as metastatic nodules). Perfusion flow, extraction fraction and blood volume; these indexes showed significant differences between malignant nodules and benign nodules with low biologic activity (P>0.0001) In addition, these indexes showed a significant difference between benign nodules with high biologic activity and those with low biologic activity (P>0.0001) and the perfusion flow was of high benefit for nodules characterization than ejection fraction and blood volume by the higher significant values. CT perfusion compared the effect of therapy (chemotherapy and or radiotherapy) on metastatic pulmonary nodules before and after start of treatment by perfusion parameters (perfusion flow, extraction fraction and blood volume) & colour maps with the clinical data and follow up revealed that both results closely near and raise the efficacy of CT perfusion study in follow up and assessment of treatment response in metastatic pulmonary nodules. It can be concluded that CT perfusion is a feasible non-invasive diagnostic technique able to evaluate the nature of pulmonary nodules and treatment response in patients with metastatic pulmonary nodules.},
 year = {2019}
}

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TY  - JOUR
T1  - Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules
AU  - Naglaa Samy Fahmy
AU  - Mohamed Ahmed Yousef
AU  - Mohamed Abd El-Hamid Alm El-Din
AU  - Abd El Monem Nooman Darweesh
Y1  - 2019/02/13
PY  - 2019
N1  - https://doi.org/10.11648/j.ijmi.20190701.11
DO  - 10.11648/j.ijmi.20190701.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20190701.11
AB  - The current study aim is the role of multi-slice CT perfusion in assessment of pulmonary nodules. Eighty patients with pulmonary nodules underwent non contrast CT scan of the chest and dynamic CT perfusion of the chest. Dynamic CT chest perfusion of 80 patients with pulmonary nodules revealed 24 patients had benign nodules of low biological activity, 16 patients had benign nodules of high biological activity and 40 patients had malignant nodules (16 of them had multiple nodules in both lung fields and clinical history of primary extra pulmonary malignancy, so diagnosed as metastatic nodules). Perfusion flow, extraction fraction and blood volume; these indexes showed significant differences between malignant nodules and benign nodules with low biologic activity (P>0.0001) In addition, these indexes showed a significant difference between benign nodules with high biologic activity and those with low biologic activity (P>0.0001) and the perfusion flow was of high benefit for nodules characterization than ejection fraction and blood volume by the higher significant values. CT perfusion compared the effect of therapy (chemotherapy and or radiotherapy) on metastatic pulmonary nodules before and after start of treatment by perfusion parameters (perfusion flow, extraction fraction and blood volume) & colour maps with the clinical data and follow up revealed that both results closely near and raise the efficacy of CT perfusion study in follow up and assessment of treatment response in metastatic pulmonary nodules. It can be concluded that CT perfusion is a feasible non-invasive diagnostic technique able to evaluate the nature of pulmonary nodules and treatment response in patients with metastatic pulmonary nodules.
VL  - 7
IS  - 1
ER  -

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Author Information

Naglaa Samy Fahmy

Radio-diagnosis & Medical Imaging Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Mohamed Ahmed Yousef

Radio-diagnosis & Medical Imaging Department, Faculty of Medicine, Tanta University, Tanta, Egypt
Mohamed Abd El-Hamid Alm El-Din

Oncology & Nuclear Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
Abd El Monem Nooman Darweesh

Radio-diagnosis & Medical Imaging Department, Faculty of Medicine, Tanta University, Tanta, Egypt

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APA Style

Naglaa Samy Fahmy, Mohamed Ahmed Yousef, Mohamed Abd El-Hamid Alm El-Din, Abd El Monem Nooman Darweesh. (2019). Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. International Journal of Medical Imaging, 7(1), 1-10. https://doi.org/10.11648/j.ijmi.20190701.11

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ACS Style

Naglaa Samy Fahmy; Mohamed Ahmed Yousef; Mohamed Abd El-Hamid Alm El-Din; Abd El Monem Nooman Darweesh. Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. Int. J. Med. Imaging 2019, 7(1), 1-10. doi: 10.11648/j.ijmi.20190701.11

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AMA Style

Naglaa Samy Fahmy, Mohamed Ahmed Yousef, Mohamed Abd El-Hamid Alm El-Din, Abd El Monem Nooman Darweesh. Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules. Int J Med Imaging. 2019;7(1):1-10. doi: 10.11648/j.ijmi.20190701.11

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@article{10.11648/j.ijmi.20190701.11,
  author = {Naglaa Samy Fahmy and Mohamed Ahmed Yousef and Mohamed Abd El-Hamid Alm El-Din and Abd El Monem Nooman Darweesh},
  title = {Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules},
  journal = {International Journal of Medical Imaging},
  volume = {7},
  number = {1},
  pages = {1-10},
  doi = {10.11648/j.ijmi.20190701.11},
  url = {https://doi.org/10.11648/j.ijmi.20190701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20190701.11},
  abstract = {The current study aim is the role of multi-slice CT perfusion in assessment of pulmonary nodules. Eighty patients with pulmonary nodules underwent non contrast CT scan of the chest and dynamic CT perfusion of the chest. Dynamic CT chest perfusion of 80 patients with pulmonary nodules revealed 24 patients had benign nodules of low biological activity, 16 patients had benign nodules of high biological activity and 40 patients had malignant nodules (16 of them had multiple nodules in both lung fields and clinical history of primary extra pulmonary malignancy, so diagnosed as metastatic nodules). Perfusion flow, extraction fraction and blood volume; these indexes showed significant differences between malignant nodules and benign nodules with low biologic activity (P>0.0001) In addition, these indexes showed a significant difference between benign nodules with high biologic activity and those with low biologic activity (P>0.0001) and the perfusion flow was of high benefit for nodules characterization than ejection fraction and blood volume by the higher significant values. CT perfusion compared the effect of therapy (chemotherapy and or radiotherapy) on metastatic pulmonary nodules before and after start of treatment by perfusion parameters (perfusion flow, extraction fraction and blood volume) & colour maps with the clinical data and follow up revealed that both results closely near and raise the efficacy of CT perfusion study in follow up and assessment of treatment response in metastatic pulmonary nodules. It can be concluded that CT perfusion is a feasible non-invasive diagnostic technique able to evaluate the nature of pulmonary nodules and treatment response in patients with metastatic pulmonary nodules.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Role of Multi-Slice Computed Tomography Perfusion in Evaluation of the Pulmonary Nodules
AU  - Naglaa Samy Fahmy
AU  - Mohamed Ahmed Yousef
AU  - Mohamed Abd El-Hamid Alm El-Din
AU  - Abd El Monem Nooman Darweesh
Y1  - 2019/02/13
PY  - 2019
N1  - https://doi.org/10.11648/j.ijmi.20190701.11
DO  - 10.11648/j.ijmi.20190701.11
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20190701.11
AB  - The current study aim is the role of multi-slice CT perfusion in assessment of pulmonary nodules. Eighty patients with pulmonary nodules underwent non contrast CT scan of the chest and dynamic CT perfusion of the chest. Dynamic CT chest perfusion of 80 patients with pulmonary nodules revealed 24 patients had benign nodules of low biological activity, 16 patients had benign nodules of high biological activity and 40 patients had malignant nodules (16 of them had multiple nodules in both lung fields and clinical history of primary extra pulmonary malignancy, so diagnosed as metastatic nodules). Perfusion flow, extraction fraction and blood volume; these indexes showed significant differences between malignant nodules and benign nodules with low biologic activity (P>0.0001) In addition, these indexes showed a significant difference between benign nodules with high biologic activity and those with low biologic activity (P>0.0001) and the perfusion flow was of high benefit for nodules characterization than ejection fraction and blood volume by the higher significant values. CT perfusion compared the effect of therapy (chemotherapy and or radiotherapy) on metastatic pulmonary nodules before and after start of treatment by perfusion parameters (perfusion flow, extraction fraction and blood volume) & colour maps with the clinical data and follow up revealed that both results closely near and raise the efficacy of CT perfusion study in follow up and assessment of treatment response in metastatic pulmonary nodules. It can be concluded that CT perfusion is a feasible non-invasive diagnostic technique able to evaluate the nature of pulmonary nodules and treatment response in patients with metastatic pulmonary nodules.
VL  - 7
IS  - 1
ER  -

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