Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science

Mersedeh Karvandi; Saeed Ranjbar; Seyed Ahmad Hassantash

doi:doi:10.11648/j.ijmi.20140202.14

| Peer-Reviewed

Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science

Mersedeh Karvandi, Saeed Ranjbar, Seyed Ahmad Hassantash

Published in International Journal of Medical Imaging (Volume 2, Issue 2)

Received: 24 February 2014 Published: 30 March 2014

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: Successful mitral valve repair and replacement are dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. The functional components of the mitral valve include: the left atrial wall, the annulus, the leaflets, the chordae tendineae, the papillary muscles, segments of the left ventricular myocardium. Abnormal anatomy or function of any one of these components can result in valvular dysfunction. We sought to assess the outcome of olden challenges of the mechanical behaviors of the mitral valve. Method: Much of our knowledge of abnormal mitral valve function is based on surgical and post-mortem studies while these studies are quantitative in some cases , they are limited by evaluation of valve anatomy in a fixed and nonfunctioning state. A more sophisticated analysis method is necessary to gain a full considerate of mitral valve function. Several groups attempted to model mitral valve anatomy and function by mathematical/physical equations. Result: Preliminary results concerning a different aspect of mitral valve leafletsbiomechanics, such as leaflets dynamics, displacements, thickness, stress and strain on leaflets. Conclusion: These data potentially allow the implementation of an image-based approach for patient-specific modeling of mitral valve leaflets. This approach could constitute the basis for accurate evaluation of mitral valve pathologic conditions and for the planning of surgical approaches.

Published in	International Journal of Medical Imaging (Volume 2, Issue 2)
DOI	10.11648/j.ijmi.20140202.14
Page(s)	24-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Mitral Valve, Mathematical Modeling, Finite Element Method, Stress-Strain of Leaflets,the Geometry of Mitral Valve, Fluid–Structure Interactions

References

[1]	Reul, H., Talukder, N., Muller, E.W. Fluid mechanics of the natural mitral valve. JBiomech1981; 14, 361–372.
[2]	Saber, N.R., Gosman, A.D., Wood, N.B., Kilner, P.J., Charrier, C.L., Firmin, D.N.Computational flow modelling of the left ventricle based on in vivo MRI data: initialexperience. Ann Biomed Eng2001; 29, 275–283.
[3]	Bacanni, B., Domenichini, F., Pedrizzetti, G. Model and influence of mitral valveopening during the left ventricular filling. J Biomech2003; 36, 355–361.
[4]	Daebritz, S.H., Sachweh, J.S., Hermanns, B., Fausten, B., Franke, A., Groetzner, J,etal. Introduction of a flexible polymeric heart valve prosthesis with special design formitral position. Circulation 2003; 108, 134–139.
[5]	Pierrakos, O., Vlachos, P.P. The effect of vortex formation on left ventricular fillingand mitral valve efficiency. J BiomechEng2006; 128, 527–539.
[6]	Grashow, J.S., Yoganathan, A.P., Sacks, M.S. Biaxial stress–stretch behavior of themitral valve anterior leaflet at physiologic strain rates. Ann Biomed Eng2006; 34, 315–325.
[7]	vanRijk-Zwikker, G.L., Delemarre, B.J., Huysmans, H.A. Mitral valve anatomy andmorphology: relevance to mitral valve replacement and reconstruction. J Card Surg1994; 9, 255–261.
[8]	Marzilli, M., Sabbah, H.N., Lee, T., Stein, P.D. Role of the papillary muscle inopening and closure of the mitral valve. Am J Physiol Heart CircPhysiol1980; 238,H348–H354.
[9]	He, Z.M., Sacks, M.S., Baijens, L., Wanant, S., Shah, P., Yoganathan, A.P. Effects ofpapillary muscle position on in-vitro dynamic strain on the porcine mitral valve. J HeartValve Dis 2003; 12, 488–494.
[10]	He, Z.M., Ritchie, J., Grashow, J.S., Sacks, M.S., Yoganathan, A.P. In vitro dynamicstrainbehaviour of the mitral valve posterior leaflet. J BiomechEng2005; 127, 504–511.
[11]	Sacks, M.S., He, Z., Baijens, L., Wanant, S., Shah, P., Sugimoto, H, et al. Surfacestrains in the anterior leaflet of the functioning mitral valve. Ann Biomed Eng2002; 30,1281–1290.
[12]	Bellhouse, B.J., Bellhouse, F.H. Fluid mechanics of the mitral valve. Nature (London).1969; 224, 615–618.
[13]	Ming, L., Zhen, H.K. Study of the closing mechanism of natural heart valves. J ApplMath mechanics 1986; 7, 955–964.
[14]	Kunzelman, K.S., Cocharan, M.D. Finite element analysis of the mitral valve.JHeartValve Dis 1993; 2, 326–340.
[15]	Kunzelman, K.S., Cochran, R.P., Verrier, E.D. Finite element analysis of mitral valvepathology. J Long Term Eff Med Implants 1993a; 3, 161–179.
[16]	Reimink, M.S., Kunzelman, K.S., Cochran, R.P. The effect of chordalreplacementsuture length on function and stresses in repaired mitral valves: a finite element study.J Heart Valve Dis 1996; 5, 365–375.
[17]	Kunzelman, K.S., Cocharan, M.D. Finite element analysis of the mitral valve. J HeartValve Dis 1993; 2, 326–340.
[18]	Kunzelman, K.S., Reimink, M.S., Cochran, R.P. Annular dilatation increases stress inthe mitral valve and delays coaptation: a finite element computer model. J CardiovascSurg1997; 5, 427–434.
[19]	Cochran, R.P., Kunzelman, K.S. Effect of papillary muscle position on mitral valvefunction: relationship to homografts. Ann ThoracSurg1998; 66, S155–S161.
[20]	Kunzelman, K.S., Cochran, R.P., Murphree, S.S., Ring, W.S., Verrier, E.D., Eberhart,R.C. Differential collagen distribution in the mitral valve and its influence onbiomechanicalbehaviour. J Heart Valve Dis 1993b; 2, 236–244.
[21]	Salgo, Ivan S., Gorman, Joseph H., Gorman, Robert C.Jackson Benjamin M. , BowenFrank W, et al. Effect of annular Shape on Leaflet Curvature in Reducing MitralLeaflet Stress. Circulation 2002; 106;711-717
[22]	Einstein, D.R., Kunzelman, K.S., Reinhall, P.G., Nicosia, M.A., Cochran, R.P. Nonlinearfluid coupled computational model of the mitral valve. J Heart Valve Dis 2005; 14,376–385.
[23]	Lim, K.H., Yeo, J.H., Duran, C.M.G. Three dimensional asymmetrical modeling of themitral valve: a finite element study with dynamic boundaries. J Heart Valve Dis 2005;14, 386–392.
[24]	Ranjbar S. Karvandi M. Ajzachi M. System and method modeling left ventricle ofheart. US Patent 2013; patent number 8,414,490.
[25]	Ranjbar S. Karvandi M. S.A. Hassantash. A novel mathematical based software formodeling the left ventricular myocardium of heart [Abstract]Euroecho2012; P448

Cite This Article

Plain Text BibTeX RIS

APA Style

Mersedeh Karvandi, Saeed Ranjbar, Seyed Ahmad Hassantash. (2014). Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. International Journal of Medical Imaging, 2(2), 24-28. https://doi.org/10.11648/j.ijmi.20140202.14

Copy | Download

ACS Style

Mersedeh Karvandi; Saeed Ranjbar; Seyed Ahmad Hassantash. Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. Int. J. Med. Imaging 2014, 2(2), 24-28. doi: 10.11648/j.ijmi.20140202.14

Copy | Download

AMA Style

Mersedeh Karvandi, Saeed Ranjbar, Seyed Ahmad Hassantash. Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. Int J Med Imaging. 2014;2(2):24-28. doi: 10.11648/j.ijmi.20140202.14

Copy | Download

@article{10.11648/j.ijmi.20140202.14,
  author = {Mersedeh Karvandi and Saeed Ranjbar and Seyed Ahmad Hassantash},
  title = {Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science},
  journal = {International Journal of Medical Imaging},
  volume = {2},
  number = {2},
  pages = {24-28},
  doi = {10.11648/j.ijmi.20140202.14},
  url = {https://doi.org/10.11648/j.ijmi.20140202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20140202.14},
  abstract = {Background: Successful mitral valve repair and replacement are dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. The functional components of the mitral valve include: the left atrial wall, the annulus, the leaflets, the chordae tendineae, the papillary muscles, segments of the left ventricular myocardium. Abnormal anatomy or function of any one of these components can result in valvular dysfunction. We sought to assess the outcome of olden challenges of the mechanical behaviors of the mitral valve. Method: Much of our knowledge of abnormal mitral valve function is based on surgical and post-mortem studies while these studies are quantitative in some cases , they are limited by evaluation of valve anatomy in a fixed and nonfunctioning state. A more sophisticated analysis method is necessary to gain a full considerate of mitral valve function. Several groups attempted to model mitral valve anatomy and function by mathematical/physical equations. Result: Preliminary results concerning a different aspect of mitral valve leafletsbiomechanics, such as leaflets dynamics, displacements, thickness, stress and strain on leaflets. Conclusion: These data potentially allow the implementation of an image-based approach for patient-specific modeling of mitral valve leaflets. This approach could constitute the basis for accurate evaluation of mitral valve pathologic conditions and for the planning of surgical approaches.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science
AU  - Mersedeh Karvandi
AU  - Saeed Ranjbar
AU  - Seyed Ahmad Hassantash
Y1  - 2014/03/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ijmi.20140202.14
DO  - 10.11648/j.ijmi.20140202.14
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20140202.14
AB  - Background: Successful mitral valve repair and replacement are dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. The functional components of the mitral valve include: the left atrial wall, the annulus, the leaflets, the chordae tendineae, the papillary muscles, segments of the left ventricular myocardium. Abnormal anatomy or function of any one of these components can result in valvular dysfunction. We sought to assess the outcome of olden challenges of the mechanical behaviors of the mitral valve. Method: Much of our knowledge of abnormal mitral valve function is based on surgical and post-mortem studies while these studies are quantitative in some cases , they are limited by evaluation of valve anatomy in a fixed and nonfunctioning state. A more sophisticated analysis method is necessary to gain a full considerate of mitral valve function. Several groups attempted to model mitral valve anatomy and function by mathematical/physical equations. Result: Preliminary results concerning a different aspect of mitral valve leafletsbiomechanics, such as leaflets dynamics, displacements, thickness, stress and strain on leaflets. Conclusion: These data potentially allow the implementation of an image-based approach for patient-specific modeling of mitral valve leaflets. This approach could constitute the basis for accurate evaluation of mitral valve pathologic conditions and for the planning of surgical approaches.
VL  - 2
IS  - 2
ER  -

Copy | Download

Author Information

Mersedeh Karvandi

Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saeed Ranjbar

Modarres Hospital, Institute of Cardiovascular Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyed Ahmad Hassantash

Modarres Hospital, Institute of Cardiovascular Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Mersedeh Karvandi, Saeed Ranjbar, Seyed Ahmad Hassantash. (2014). Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. International Journal of Medical Imaging, 2(2), 24-28. https://doi.org/10.11648/j.ijmi.20140202.14

Copy | Download

ACS Style

Mersedeh Karvandi; Saeed Ranjbar; Seyed Ahmad Hassantash. Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. Int. J. Med. Imaging 2014, 2(2), 24-28. doi: 10.11648/j.ijmi.20140202.14

Copy | Download

AMA Style

Mersedeh Karvandi, Saeed Ranjbar, Seyed Ahmad Hassantash. Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science. Int J Med Imaging. 2014;2(2):24-28. doi: 10.11648/j.ijmi.20140202.14

Copy | Download

@article{10.11648/j.ijmi.20140202.14,
  author = {Mersedeh Karvandi and Saeed Ranjbar and Seyed Ahmad Hassantash},
  title = {Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science},
  journal = {International Journal of Medical Imaging},
  volume = {2},
  number = {2},
  pages = {24-28},
  doi = {10.11648/j.ijmi.20140202.14},
  url = {https://doi.org/10.11648/j.ijmi.20140202.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20140202.14},
  abstract = {Background: Successful mitral valve repair and replacement are dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. The functional components of the mitral valve include: the left atrial wall, the annulus, the leaflets, the chordae tendineae, the papillary muscles, segments of the left ventricular myocardium. Abnormal anatomy or function of any one of these components can result in valvular dysfunction. We sought to assess the outcome of olden challenges of the mechanical behaviors of the mitral valve. Method: Much of our knowledge of abnormal mitral valve function is based on surgical and post-mortem studies while these studies are quantitative in some cases , they are limited by evaluation of valve anatomy in a fixed and nonfunctioning state. A more sophisticated analysis method is necessary to gain a full considerate of mitral valve function. Several groups attempted to model mitral valve anatomy and function by mathematical/physical equations. Result: Preliminary results concerning a different aspect of mitral valve leafletsbiomechanics, such as leaflets dynamics, displacements, thickness, stress and strain on leaflets. Conclusion: These data potentially allow the implementation of an image-based approach for patient-specific modeling of mitral valve leaflets. This approach could constitute the basis for accurate evaluation of mitral valve pathologic conditions and for the planning of surgical approaches.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Mechanical Mitral Valve Modeling: Advancing the Field through Emerging Science
AU  - Mersedeh Karvandi
AU  - Saeed Ranjbar
AU  - Seyed Ahmad Hassantash
Y1  - 2014/03/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ijmi.20140202.14
DO  - 10.11648/j.ijmi.20140202.14
T2  - International Journal of Medical Imaging
JF  - International Journal of Medical Imaging
JO  - International Journal of Medical Imaging
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2330-832X
UR  - https://doi.org/10.11648/j.ijmi.20140202.14
AB  - Background: Successful mitral valve repair and replacement are dependent upon a full understanding of normal and abnormal mitral valve anatomy and function. The functional components of the mitral valve include: the left atrial wall, the annulus, the leaflets, the chordae tendineae, the papillary muscles, segments of the left ventricular myocardium. Abnormal anatomy or function of any one of these components can result in valvular dysfunction. We sought to assess the outcome of olden challenges of the mechanical behaviors of the mitral valve. Method: Much of our knowledge of abnormal mitral valve function is based on surgical and post-mortem studies while these studies are quantitative in some cases , they are limited by evaluation of valve anatomy in a fixed and nonfunctioning state. A more sophisticated analysis method is necessary to gain a full considerate of mitral valve function. Several groups attempted to model mitral valve anatomy and function by mathematical/physical equations. Result: Preliminary results concerning a different aspect of mitral valve leafletsbiomechanics, such as leaflets dynamics, displacements, thickness, stress and strain on leaflets. Conclusion: These data potentially allow the implementation of an image-based approach for patient-specific modeling of mitral valve leaflets. This approach could constitute the basis for accurate evaluation of mitral valve pathologic conditions and for the planning of surgical approaches.
VL  - 2
IS  - 2
ER  -

Copy | Download