Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation of cells with a Langerhans cell phenotype, which comprises a wide range of clinical presentations. The reported patient is a 55-year old female with multy-sistem LCH and pulmonary tuberculosis. During diagnostic processing, infiltrates of Langerhans cells (S-100+, CD1a+) in the epidermis, intestinal mucosa and bone marrow, were discovered. Transbronchial needle biopsy of the lung revealed non-specific clusters of macrophages (CD68+, CD1a-). Although CD1a was negative, positive CD68, thoracic MSCT and clinical findings indicated pulmonary LCH. Corticosteroid treatment led to significant clinical improvement. Seven months after treatment with corticosteroids the patient developed a spontaneous left-sided pneumothorax. Thoracic HR (high resolution)-MSCT was highly suggestive for active Mycobacterium tuberculosis (MT) infection together with the positive QUANTIFERON-TB test and typical symptoms. One week after starting standard triple antituberculotic therapy the patient developed hypovolemic shock. Despite all medical efforts, the patient died on the thirteenth day of intensive treatment for multiple organ failure.
| Published in | Clinical Medicine Research (Volume 6, Issue 4) |
| DOI | 10.11648/j.cmr.20170604.15 |
| Page(s) | 139-142 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2017. Published by Science Publishing Group |
Langerhans-Cell Histiocytosis, Pulmonary Tuberculosis, Multislice Computed Tomography, Corticosteroids, Multiple Organ Failure
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APA Style
Veljko Flego, Darian Volaric. (2017). Multisystem Langerhans Cell Histiocytosis with Fatal Outcome in Adult Patient: A Case Report. Clinical Medicine Research, 6(4), 139-142. https://doi.org/10.11648/j.cmr.20170604.15
ACS Style
Veljko Flego; Darian Volaric. Multisystem Langerhans Cell Histiocytosis with Fatal Outcome in Adult Patient: A Case Report. Clin. Med. Res. 2017, 6(4), 139-142. doi: 10.11648/j.cmr.20170604.15
AMA Style
Veljko Flego, Darian Volaric. Multisystem Langerhans Cell Histiocytosis with Fatal Outcome in Adult Patient: A Case Report. Clin Med Res. 2017;6(4):139-142. doi: 10.11648/j.cmr.20170604.15
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Download@article{10.11648/j.cmr.20170604.15,
author = {Veljko Flego and Darian Volaric},
title = {Multisystem Langerhans Cell Histiocytosis with Fatal Outcome in Adult Patient: A Case Report},
journal = {Clinical Medicine Research},
volume = {6},
number = {4},
pages = {139-142},
doi = {10.11648/j.cmr.20170604.15},
url = {https://doi.org/10.11648/j.cmr.20170604.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.15},
abstract = {Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation of cells with a Langerhans cell phenotype, which comprises a wide range of clinical presentations. The reported patient is a 55-year old female with multy-sistem LCH and pulmonary tuberculosis. During diagnostic processing, infiltrates of Langerhans cells (S-100+, CD1a+) in the epidermis, intestinal mucosa and bone marrow, were discovered. Transbronchial needle biopsy of the lung revealed non-specific clusters of macrophages (CD68+, CD1a-). Although CD1a was negative, positive CD68, thoracic MSCT and clinical findings indicated pulmonary LCH. Corticosteroid treatment led to significant clinical improvement. Seven months after treatment with corticosteroids the patient developed a spontaneous left-sided pneumothorax. Thoracic HR (high resolution)-MSCT was highly suggestive for active Mycobacterium tuberculosis (MT) infection together with the positive QUANTIFERON-TB test and typical symptoms. One week after starting standard triple antituberculotic therapy the patient developed hypovolemic shock. Despite all medical efforts, the patient died on the thirteenth day of intensive treatment for multiple organ failure.},
year = {2017}
}
TY - JOUR T1 - Multisystem Langerhans Cell Histiocytosis with Fatal Outcome in Adult Patient: A Case Report AU - Veljko Flego AU - Darian Volaric Y1 - 2017/07/26 PY - 2017 N1 - https://doi.org/10.11648/j.cmr.20170604.15 DO - 10.11648/j.cmr.20170604.15 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 139 EP - 142 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20170604.15 AB - Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation of cells with a Langerhans cell phenotype, which comprises a wide range of clinical presentations. The reported patient is a 55-year old female with multy-sistem LCH and pulmonary tuberculosis. During diagnostic processing, infiltrates of Langerhans cells (S-100+, CD1a+) in the epidermis, intestinal mucosa and bone marrow, were discovered. Transbronchial needle biopsy of the lung revealed non-specific clusters of macrophages (CD68+, CD1a-). Although CD1a was negative, positive CD68, thoracic MSCT and clinical findings indicated pulmonary LCH. Corticosteroid treatment led to significant clinical improvement. Seven months after treatment with corticosteroids the patient developed a spontaneous left-sided pneumothorax. Thoracic HR (high resolution)-MSCT was highly suggestive for active Mycobacterium tuberculosis (MT) infection together with the positive QUANTIFERON-TB test and typical symptoms. One week after starting standard triple antituberculotic therapy the patient developed hypovolemic shock. Despite all medical efforts, the patient died on the thirteenth day of intensive treatment for multiple organ failure. VL - 6 IS - 4 ER -
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