Metabolic Abnormalities in Colorectal Cancer Patients

Zhukov V. I.; Vinnik Y. A.; Perepadya S. V.; Moiseenko A. S.; Gramatyuk S. N.

doi:doi:10.11648/j.ajns.20130202.12

| Peer-Reviewed

Metabolic Abnormalities in Colorectal Cancer Patients

Zhukov V. I., Vinnik Y. A., Perepadya S. V., Moiseenko A. S., Gramatyuk S. N.

Published in American Journal of Nursing Science (Volume 2, Issue 2)

Published: 2 April 2013

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and function-ing properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes.

Published in	American Journal of Nursing Science (Volume 2, Issue 2)
DOI	10.11648/j.ajns.20130202.12
Page(s)	18-20
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

HOMA-IR, Lipid Metabolism, Colorectal Cancer Patients

References

[1]	Cancer. National Cancer Institute. USA 2009.
[2]	Zhang X, Smith-Warner SA, Chan AT, Wu K, Spiegelman D, Fuchs CS, Willett WC, et al. Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals. Am J Epidemiol. 2011;174(4):459-467.
[3]	Fernandez E, Gallus S, La Vecchia C, Talamini R, Negri E, Franceschi S. Family history and environmental risk factors for colon cancer. Cancer Epidemiol Biomarkers Prev. 2004;13(4):658-661.
[4]	Stachowicz M, Mazurek U, Nowakowska-Zajdel E, Niedworok E, Fatyga E, Muc-Wierzgon M. Leptin and its receptors in obese patients with colorectal cancer. J Biol Regul Homeost Agents. 2010;24(3):287-295.
[5]	Jain, S.K., Mcvie, R., Duett, J. and Herbst, J.J. (1989) Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 38, 1539-1542.
[6]	Warholm, M., Guthenberg, C., Christer von Bahr and Mannervik, B. (1985) Glutathione transferases from human liver. In: Methods of enzymology. Alton Meister (Ed.). Academic Press, Vol 113, p. 500-501.
[7]	Ahmed, M.I., Fayed, S.T., Hossein, H. and Tash, F.M. (1999) Lipid peroxidation and antioxidant status in human cervical carcinoma. Dis. Markers 15, 283-291.
[8]	Legouffe E, Rodriguez C, Picot MC, Richard B, Klein B, Rossi JF. C-reactive protein serum level is a valuable and simple prognostic marker in non-Hodgkin's lymphoma. Leuk Lymphoma 1998;31:351-7.
[9]	Falconer JS, Fearon KCH, Ross JA, Elton R, Wigmor ST, Garden OJ. Acute-phase protein response and survival in pancreatic cancer. Cancer 1995;75:2077-82.
[10]	Nozoe T, Saeki H, Sugimachi K. Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma. Am J Surg 2001;182:197-201.
[11]	Trautner K, Cooper EH, Haworth S, Ward AM. An evaluation of serum protein profiles in the long-term surveillance of prostatic cancer. Scand J Urol Nephrol 1980;14:143-9.
[12]	Latif Z, McMillan DC, Wallace AM, Sattar N, Mir K, Jones G, Underwood MA. The relationship of circulating insulin-like growth factor 1, its binding protein-3, prostate-specific antigen and C-reactive protein with disease stage in prostate cancer. BJU Int 2002;89:396-9.

Cite This Article

Plain Text BibTeX RIS

APA Style

Zhukov V. I., Vinnik Y. A., Perepadya S. V., Moiseenko A. S., Gramatyuk S. N. (2013). Metabolic Abnormalities in Colorectal Cancer Patients. American Journal of Nursing Science, 2(2), 18-20. https://doi.org/10.11648/j.ajns.20130202.12

Copy | Download

ACS Style

Zhukov V. I.; Vinnik Y. A.; Perepadya S. V.; Moiseenko A. S.; Gramatyuk S. N. Metabolic Abnormalities in Colorectal Cancer Patients. Am. J. Nurs. Sci. 2013, 2(2), 18-20. doi: 10.11648/j.ajns.20130202.12

Copy | Download

AMA Style

Zhukov V. I., Vinnik Y. A., Perepadya S. V., Moiseenko A. S., Gramatyuk S. N. Metabolic Abnormalities in Colorectal Cancer Patients. Am J Nurs Sci. 2013;2(2):18-20. doi: 10.11648/j.ajns.20130202.12

Copy | Download

@article{10.11648/j.ajns.20130202.12,
  author = {Zhukov V. I. and Vinnik Y. A. and Perepadya S. V. and Moiseenko A. S. and Gramatyuk S. N.},
  title = {Metabolic Abnormalities in Colorectal Cancer Patients},
  journal = {American Journal of Nursing Science},
  volume = {2},
  number = {2},
  pages = {18-20},
  doi = {10.11648/j.ajns.20130202.12},
  url = {https://doi.org/10.11648/j.ajns.20130202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20130202.12},
  abstract = {Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and function-ing properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Metabolic Abnormalities in Colorectal Cancer Patients
AU  - Zhukov V. I.
AU  - Vinnik Y. A.
AU  - Perepadya S. V.
AU  - Moiseenko A. S.
AU  - Gramatyuk S. N.
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.ajns.20130202.12
DO  - 10.11648/j.ajns.20130202.12
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 18
EP  - 20
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20130202.12
AB  - Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and function-ing properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes.
VL  - 2
IS  - 2
ER  -

Copy | Download

Author Information

Zhukov V. I.

Department of Biochemistry, Kharkov National Medical University
Vinnik Y. A.

Kharkov Clinic Oncologic Centre
Perepadya S. V.

Kharkov Clinic Oncologic Centre
Moiseenko A. S.

Kharkov Clinic Oncologic Centre
Gramatyuk S. N.

Kharkov Clinic Oncologic Centre

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Zhukov V. I., Vinnik Y. A., Perepadya S. V., Moiseenko A. S., Gramatyuk S. N. (2013). Metabolic Abnormalities in Colorectal Cancer Patients. American Journal of Nursing Science, 2(2), 18-20. https://doi.org/10.11648/j.ajns.20130202.12

Copy | Download

ACS Style

Zhukov V. I.; Vinnik Y. A.; Perepadya S. V.; Moiseenko A. S.; Gramatyuk S. N. Metabolic Abnormalities in Colorectal Cancer Patients. Am. J. Nurs. Sci. 2013, 2(2), 18-20. doi: 10.11648/j.ajns.20130202.12

Copy | Download

AMA Style

Zhukov V. I., Vinnik Y. A., Perepadya S. V., Moiseenko A. S., Gramatyuk S. N. Metabolic Abnormalities in Colorectal Cancer Patients. Am J Nurs Sci. 2013;2(2):18-20. doi: 10.11648/j.ajns.20130202.12

Copy | Download

@article{10.11648/j.ajns.20130202.12,
  author = {Zhukov V. I. and Vinnik Y. A. and Perepadya S. V. and Moiseenko A. S. and Gramatyuk S. N.},
  title = {Metabolic Abnormalities in Colorectal Cancer Patients},
  journal = {American Journal of Nursing Science},
  volume = {2},
  number = {2},
  pages = {18-20},
  doi = {10.11648/j.ajns.20130202.12},
  url = {https://doi.org/10.11648/j.ajns.20130202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajns.20130202.12},
  abstract = {Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and function-ing properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Metabolic Abnormalities in Colorectal Cancer Patients
AU  - Zhukov V. I.
AU  - Vinnik Y. A.
AU  - Perepadya S. V.
AU  - Moiseenko A. S.
AU  - Gramatyuk S. N.
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.ajns.20130202.12
DO  - 10.11648/j.ajns.20130202.12
T2  - American Journal of Nursing Science
JF  - American Journal of Nursing Science
JO  - American Journal of Nursing Science
SP  - 18
EP  - 20
PB  - Science Publishing Group
SN  - 2328-5753
UR  - https://doi.org/10.11648/j.ajns.20130202.12
AB  - Normally, cells grow, divide and produce more cells as they are needed to keep the body healthy and function-ing properly. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Aim of the research. The aim of the study was to estimate of the association between the anthropometric obesity, fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides, a homeostasis model of assessment (HOMA-IR) colorectal cancer patients. Colon cancer was diagnosed in 239 patients aged from 35 to 76 years. For each patient, the following data were considered: anthropometric measurements (weight, height, waist circumference values), fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides. Also, three index: BMI (Body Mass Index; kg/m2) HOMA-IR (Homeostasis Model of Assessment - Insulin Resistance; fasting glucose (mmol/L) x fasting insulin (mU/L)/22.5). The average fasting serum concentration of glucose, glycosylated hemoglobin, insulin, total cholesterol, HDL/LDL fractions, triglycerides and HOMA-IR index were statistically significantly higher in patients transverse colon cancer (P < 0.001). Triglycerides increased with the appropriate forms of CRC by 58.8%, 47%, 52.9% and 64.7%. Studies have shown a violation of the protein and lipid metabolism in patients with colon carcinogenesis, which should be assumed to prevail over anabolic processes.
VL  - 2
IS  - 2
ER  -

Copy | Download